Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.
نویسندگان
چکیده
منابع مشابه
Metabolism of Exogenous Diacylglycerols by Human Platelets*
The metabolism of exogenous [3H]diacylglycerols by intact human platelets was studied in order to examine: 1) the metabolic fate of these second messengers in an intact cell, 2) the effect of diacylglycerol kinase and diacylglycerol lipase inhibitors on this metabolism, 3) the effect of agonist stimulation on metabolism, and 4) the dependence of metabolism on diacylglycerol chain length. When 2...
متن کاملExogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
The ability of exogenous sn-1,2-diacylglycerols and analogs to function as bioregulators of protein kinase C in human platelets was investigated. The activation of protein kinase C in platelets is indicated by specific phosphorylation of a 40,000-dalton protein. Dihexanoylglycerol, dioctanoylglycerol (diC8), didecanoylglycerol, and sn-1-oleoyl-2-acetylglycerol were active in stimulating 40,000-...
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Hormones and neurotransmitters that use calcium as a second messenger specifically hydrolyse membrane phosphoinositides. This perturbation of membrane phospholipids may represent a fundamental transducing mechanism that initiates a signal cascade resulting in the mobilization of calcium, the activation of protein kinase C, the release of arachidonic acid (for the synthesis of prostaglandins, th...
متن کاملRegulation of sn-1,2-diacylglycerol second-messenger formation in thrombin-stimulated human platelets. Potentiation by protein kinase C inhibitors.
Stimulation of platelets with thrombin leads to rapid degradation of inositol phospholipids, generation of diacylglycerol (DAG) and subsequent activation of protein kinase C (PKC). Previous studies indicated that prior activation of PKC with phorbol myristate acetate (PMA) desensitizes platelets to thrombin stimulation, as indicated by a decreased production of inositol phosphates and decreased...
متن کاملsecond language acquisition of telicity and aspect by persian learners of english
این تحقیق از دو قسمت اصلی تشکیل شده است: در قسمت اول فراگیری ختمیت به ویژه درک و تولید اینگونه جملات توسط فراگیران ایرانی زبان انگلیسی مورد بررسی قرار گرفته است. قضاوت تعدادی انگلیسی زبان بر روی این جملات نیز هدفی دیگر بود که در این رساله بررسی شده است. از موضوعات دیگر تفاوت بین نشانه های ختمیت در زبان انگلیسی و فارسی و تاثیر زبان اول فراگیران در درک و تولید اینگونه جملات است. در قسمت دوم استفا...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1986
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)67117-0